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Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

In the later stage of injury, the continuously high expression of MMP-9 not only hinders the normal reconstruction of ECM, but also the fragments produced by its degradation of ECM and the released/activated latent growth factors may instead promote the proliferation, migration and transformation into myofibroblasts of fibroblasts, driving the abnormal pathological fibrosis process ( 2.5.2 Hirsutanol A and fucoidan alleviate lung injury through the regulation of matrix metalloproteinase-9 (MMP-9) and fibroblast function Animal experiments have confirmed that in acute lung injury complicated with LPS-induced endotoxemia, Hirsutanol A (HA) derived from the Marine fungus Chondrostereum sp

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[DOI] [PubMed] [Google Scholar] 55.Kalderon B, Mayorek N, Berry E, Zevit N, Bar-Tana J

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